Alcorn State University is approximately an equal distance - 40 miles - from Vicksburg to the north and Natchez to the south. The University is 80 miles southwest of the state capital, Jackson.  From the east or west via I-20: Take the U.S. Hwy 61 exit, travel approximately 40 miles, and exit onto Mississippi Hwy 552 west. Follow the signs for 7 miles to the campus.  From the north or south via I-55: (1) From I-55 in Jackson, MS take take I-20 west to Vicksburg, MS. Take the exit to U.S. Hwy 61 south to MS Hwy 552 west. (2) From I-55 at Brookhaven, MS take U.S. Hwy 84 west to MS Hwy 33 north, to US Hwy 61 north to US Hwy 552 west. (3) From I-55 at McComb, MS take U.S. Hwy 98 west to U.S. Hwy 84 west at Bude, to MS Hwy 33 N to U.S. Hwy 61 north to MS Hwy 552 west.

Jackson, MS is served by Amtrak and most major airlines. Greyhound/Trailways bus service is available to Port Gibson, approximately 20 minutes from campus. With advance arrangements, visiting students may call Campus Police at (601)877-6390 for pick up in Port Gibson.