From the east or west via I-20: Take the U.S. Hwy 61 exit, travel approximately 40 miles, and exit onto Mississippi Hwy 552 west. Follow the signs for 7 miles to the campus. 

From the north or south via I-55:
(1) From I-55 in Jackson, MS take take I-20 west to Vicksburg, MS. Take the exit to U.S. Hwy 61 south to MS Hwy 552 west.
(2) From I-55 at Brookhaven, MS take U.S. Hwy 84 west to MS Hwy 33 north, to US Hwy 61 north to US Hwy 552 west.
(3) From I-55 at McComb, MS take U.S. Hwy 98 west to U.S. Hwy 84 west at Bude, to MS Hwy 33 N to U.S. Hwy 61 north to MS Hwy 552 west.